CHOREIN-DEPENDENT MICROFILAMENT ORGANIZATION IN TUMOR CELLS

Chorein-dependent microfilament organization in tumor cells

Chorein is variably expressed in different cancer cells.In various non-malignant cell types, this protein regulates cytoskeleton microstructure and signaling.However, the role of chorein in regulating the actin cytoskeleton in tumor cells remains elusive.Here, we investigated chorein expression in various breast tumor cells and the involvement of t

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Enzymatic blockade of the ubiquitin-proteasome pathway.

Ubiquitin-dependent processes control much of cellular physiology.We show that expression of a highly active, Epstein-Barr virus-derived deubiquitylating enzyme (EBV-DUB) blocks proteasomal degradation of cytosolic and ER-derived proteins by Handlebar preemptive removal of ubiquitin from proteasome substrates, a treatment less toxic than the use of

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